HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1960245Generated: October 26, 2026
Lawesson's reagent → 7-[methyl(2-thienylsulfonyl)amino]-1H-indole-2-carbothioamide
https://huagongshe.com/reaction/1960245
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Lawesson's reagent | HCID 87949 | — |
| Reactant | 7-[methyl(2-thienylsulfonyl)amino]-1H-indole-2-carboxamide | HCID 57475953 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 7-[methyl(2-thienylsulfonyl)amino]-1H-indole-2-carbothioamide | HCID 57475960 | 93% |
Reaction Steps
A mixture of 7-[methyl(2-thienylsulfonyl)amino]-1H-indole-2-carboxamide (11.47 g), Lawesson's reagent (15.2 g) and tetrahydrofuran (150 ml) was stirred at 50° C. for 4 hr. The reaction mixture was concentrated, and the resulting crystals were filtrated, washed with toluene, and dried to give the title compound (11.16 g, yield 93%) as yellow crystals. melting point 239-240° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08410087B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-e69e4de094ce41ddbd01288a9a3c8c1e |
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| Source note | uspto-grants-2013_04 |
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