Pyridine → Laquinimod

HRID 196027Notes

Reaction equation

HRID 196027 reaction equation
[CH2:25]([CH3:26])[NH:27][c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1.[CH3:18][c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1.[OH:1][c:2]1[c:3]([C:15](=[O:16])[OH:17])[c:4](=[O:14])[n:5]([CH3:13])[c:6]2[cH:7][cH:8][cH:9][c:10]([Cl:12])[c:11]12.[S:34]([Cl:35])([Cl:36])=[O:37].[cH:38]1[cH:39][cH:40][n:41][cH:42][cH:43]1>>[OH:1][c:2]1[c:3]([C:15](=[O:17])[N:27]([CH2:25][CH3:26])[c:28]2[cH:29][cH:30][cH:31][cH:32][cH:33]2)[c:4](=[O:14])[n:5]([CH3:13])[c:6]2[cH:7][cH:8][cH:9][c:10]([Cl:12])[c:11]12

Participants

6

Reactant 5

HCID 1049PyridineHCID 1140TolueneHCID 7670N-EthylanilineHCID 24386Thionyl ChlorideHCID 547202275-Chloro-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid

Product 1

HCID 54677946Laquinimod

Sources & evidence

ORD record
ord-adbaea14e4844ce691b2a1573ac04297
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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