HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 19604Generated: October 26, 2026
7-Methanesulfonyl-5-(4'-methoxy-biphenyl-3-yl)-pyrazolo[1,5-c]pyrimidine → (4-{4-[5-(4'-Methoxy-biphenyl-3-yl)-pyrazolo[1,5-c]pyrimidin-7-ylamino]-phenylcarbamoyl}-benzyl)-carbamic acid tert-butyl ester
https://huagongshe.com/reaction/19604
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 7-Methanesulfonyl-5-(4'-methoxy-biphenyl-3-yl)-pyrazolo[1,5-c]pyrimidine | HCID 67317653 | — |
| Reactant | [4-(4-Amino-phenylcarbamoyl)-benzyl]-carbamic acid tert-butyl ester | HCID 67319189 | — |
| Product | (4-{4-[5-(4'-Methoxy-biphenyl-3-yl)-pyrazolo[1,5-c]pyrimidin-7-ylamino]-phenylcarbamoyl}-benzyl)-carbamic acid tert-butyl ester | HCID 67319203 | — |
Reaction Steps
Under an inert gas atmosphere at 130° C. bath temperature is heated neat a mixture of 7-methanesulfonyl-5-(4′-methoxy-biphenyl-3-yl)-pyrazolo[1,5-c]pyrimidine and [4-(4-amino-phenylcarbamoyl)-benzyl]-carbamic acid tertbutyl ester (compound B3) overnight. The crude product is purified by silica gel flash chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07745446B2 |
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| Source dataset | uspto-grants-2010_06 |
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| ORD ID | ord-4b05f3aff05e4cd38be34cf9b4a03da6 |
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| Source note | uspto-grants-2010_06 |
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