HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Methoxy-3-pyridinylamine → HCID 22060333, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Methoxy-3-pyridinylamine | HCID 81121 | — |
| Reactant | 2,4-Dichloro-5-fluoropyrimidine | HCID 250705 | — |
| Product | HCID 22060333 | HCID 22060333 | — |
Reaction Steps
In like manner to the preparation of 2-chloro-5-fluoro-N4-[3-(1H-tetrazol-5-yl)phenyl]-4-pyrimidineamine the reaction of 2,4-dichloro-5-fluoropyrimidine with 3-amino-6-methoxypyridine gave 2-chloro-5-fluoro-N4-(6-methoxypyridin-3-yl)-4-pyrimidineamine. 1H NMR (CD3OD): δ 8.39 (d, 1H, J=3.0 Hz), 8.10 (d, 1H, J=3.6 Hz), 7.95 (dd, 1H, J=2.4 and 9 Hz), 8.30 (d, 1H, J=9 Hz), 3.91 (s, 3H); 19F NMR (CD3OD): −44737; LCMS: purity: 97%; MS (m/e): 255 (M+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08410266B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-971ec098b4af47f7aae57c5c1c93c531 |
| Source note | uspto-grants-2013_04 |