HRID19608

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID688611

tert-Butyl (4-aminophenyl)carbamate

C11H16N2O2

结构：CS(=O)(=O)c1nc(-c2ccc3cc(OCc4ccccc4)ccc3c2)cc2ccnn12

HCID67319776

未命名化合物

2 次

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)Nc1ccc(Nc2nc(-c3ccc4cc(OCc5ccccc5)ccc4c3)cc3ccnn23)cc1

HCID67319245

未命名化合物

收率 46%

CONDITIONS

反应条件

温度: 135 °C

PROCEDURE

实验过程

A mixture of 5-(6-benzyloxy-naphthalen-2-yl)-7-methanesulfonyl-pyrazolo[1,5-c]pyrimidine (compound D2)(87 mg) and 4-amino-phenyl-carbamic acid tert-butyl ester (208 mg) is heated neat at 130 to 140° C. bath temperature for 20 min. After cooling, the crude product is purified by silica gel flash chromatography. A nearly colorless solid (51 mg, 46%) with melting temperature of 189° C. is obtained.

WORKUP

后处理

temperatureAfter cooling
customthe crude product is purified by silica gel flash chromatography

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-511010926b6f4983a5ba276bd9effa2d
来源数据集: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07745446B2
来源说明: uspto-grants-2010_06

反应 SMILES

[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[CH:15]=[C:14]([C:19]1[N:24]=[C:23](S(C)(=O)=O)[N:22]3[N:29]=[CH:30][CH:31]=[C:21]3[CH:20]=1)[CH:13]=[CH:12]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:32]([O:36][C:37](=[O:46])[NH:38][C:39]1[CH:44]=[CH:43][C:42]([NH2:45])=[CH:41][CH:40]=1)([CH3:35])([CH3:34])[CH3:33]>>[C:32]([O:36][C:37](=[O:46])[NH:38][C:39]1[CH:40]=[CH:41][C:42]([NH:45][C:23]2[N:22]3[N:29]=[CH:30][CH:31]=[C:21]3[CH:20]=[C:19]([C:14]3[CH:13]=[CH:12][C:11]4[C:16](=[CH:17][CH:18]=[C:9]([O:8][CH2:1][C:2]5[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=5)[CH:10]=4)[CH:15]=3)[N:24]=2)=[CH:43][CH:44]=1)([CH3:35])([CH3:33])[CH3:34]