Ethyl 3-aminobenzoate → HCID 22060542, compound

HRID 1960889Notes

Reaction equation

HRID 1960889 reaction equation
Cl[C:2]1[N:7]=[C:6](Cl)[C:5]([F:9])=[CH:4][N:3]=1.[CH2:10]([O:12][C:13]([C:15]1[CH:16]=[C:17]([CH:19]=[CH:20][CH:21]=1)[NH2:18])=[O:14])[CH3:11]>>[CH2:10]([O:12][C:13]([C:15]1[CH:16]=[C:17]([NH:18][C:2]2[N:7]=[C:6]([NH:18][C:17]3[CH:19]=[CH:20][CH:21]=[C:15]([C:13]([O:12][CH2:10][CH3:11])=[O:14])[CH:16]=3)[C:5]([F:9])=[CH:4][N:3]=2)[CH:19]=[CH:20][CH:21]=1)=[O:14])[CH3:11]

Participants

3

Reactant 2

HCID 11400Ethyl 3-aminobenzoateHCID 2507052,4-Dichloro-5-fluoropyrimidine

Product 1

HCID 22060542HCID 22060542, compound

Procedure

In like manner to the preparation of N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine, the reaction of 2,4-dichloro-5-fluoropyrimidine and 3-ethoxycarbonylaniline gave N2,N4-bis(3-ethoxycarbonylphenyl)-5-fluoro-2,4-pyrimidinediamine. LCMS: ret. time: 26.55 min.; purity: 100%; MS (m/e): 425 (MH+).

Workup

  1. customIn like manner to the preparation of N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine

Sources & evidence

ORD record
ord-7d1f0af3aeda4c7fa8cbee1739d056b1
Source dataset
uspto-grants-2013_04
Patent number
US08410266B2

Reaction notes

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