反应详情

温度

55 °C

To a solution of 5-chloro-2-thiophenecarboxylic acid (20 g, 123 mmoles) in MeOH (200 mL) was added conc. H2SO4 (5 mL). After heating to 55° C. for 12 h, the reaction solution was concentrated and diluted with DCM (250 mL). The DCM solution was washed with aqueous NaHCO3, then H2O and dried over Na2SO4. Concentration under vacuum gave the title compound as a yellow oil (21.5 g, 99%): LCMS (ES) m/z 178 (M+H)+.

1. concentrationthe reaction solution was concentrated
2. additiondiluted with DCM (250 mL)
3. washThe DCM solution was washed with aqueous NaHCO3
4. dry with materialH2O and dried over Na2SO4
5. concentrationConcentration under vacuum