Ammonia → 3-bromo-1-(1,4-dioxaspiro[4.5]dec-8-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine

HRID 196120Notes

Reaction equation

HRID 196120 reaction equation
[Br:1][c:2]1[n:3][n:4]([CH:12]2[CH2:13][CH2:14][C:15]3([O:16][CH2:17][CH2:18][O:19]3)[CH2:20][CH2:21]2)[c:5]2[n:6][cH:7][n:8][c:9]([Cl:11])[c:10]12.[NH3:22].[O:23]1[CH2:24][CH2:25][O:26][CH2:27][CH2:28]1>>[Br:1][c:2]1[n:3][n:4]([CH:12]2[CH2:13][CH2:14][C:15]3([O:16][CH2:17][CH2:18][O:19]3)[CH2:20][CH2:21]2)[c:5]2[n:6][cH:7][n:8][c:9]([NH2:22])[c:10]12

Participants

4

Reactant 3

HCID 222AmmoniaHCID 312751,4-DioxaneHCID 223470503-bromo-4-chloro-1-(1,4-dioxaspiro[4.5]dec-8-yl)-1H-pyrazolo[3,4-d]pyrimidine

Product 1

HCID 223472163-bromo-1-(1,4-dioxaspiro[4.5]dec-8-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine

Sources & evidence

ORD record
ord-b09c6e3f0e954fcdbad4ba847a2db609
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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