HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1961290Generated: November 1, 2026
Potassium Carbonate → methyl 4-(1-ethyl-4-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxylate
https://huagongshe.com/reaction/1961290
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 4-bromothiophene-2-carboxylate | HCID 12752071 | — |
| Reactant | 1-ethyl-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole | HCID 57826915 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | methyl 4-(1-ethyl-4-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxylate | HCID 57826708 | 79.3% |
Reaction Steps
A mixture of methyl 4-bromo-2-thiophenecarboxylate (300 mg, 1.36 mmol), 1-ethyl-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (449 mg, 1.9 mmol), Pd(Ph3P)4 (157 mg, 0.136 mmol), and K2CO3 (536 mg, 4.07 mmol) was heated at 70° C. for 2 h, concentrated and purified on silica (EtOAc/Hex, 10-30%) to afford the title compound (0.27 g, 79%) as a syrup: LC-MS m/z=251 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08410158B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-cca33fdc309e4c8287ef7db98812adc4 |
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| Source note | uspto-grants-2013_04 |
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