HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1961350Generated: October 31, 2026
Diisopropylethylamine → 6-(2,5-Difluorophenyl)-3,4-dihydro-3-methylene-5-nitro-2H-pyran
https://huagongshe.com/reaction/1961350
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 3-Iodo-2-(iodomethyl)prop-1-ene | HCID 11045029 | — |
| Reactant | HCID 57371203 | HCID 57371203 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-(2,5-Difluorophenyl)-3,4-dihydro-3-methylene-5-nitro-2H-pyran | HCID 57519248 | — |
Reaction Steps
N,N-diisopropylethylamine (184 mL) was added to a solution of 2-nitro-1-(2,5-difluorophenyl)ethanone (92.7 g, 461 mmol) in N,N-dimethylformamide (1000 mL) and 3-iodo-2-(iodomethyl)prop-1-ene (156 g, 507 mmol). The mixture was heated at 60° C. for 2 h, evaporated and purified by chromatography (silica gel, gradient 0-30% dichloromethane in hexane) to yield 3-methylene-5-nitro-6-(2,5-difluorophenyl)-3,4-dihydro-2H-pyran.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08415297B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-1741590e70b041bf959e7a26e3d0db5c |
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| Source note | uspto-grants-2013_04 |
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