HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 6-(Trifluoromethyl)benzo[b]thiophene-2-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 6-(Trifluoromethyl)benzo[b]thiophene-2-carboxylic acid | HCID 17979523 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-(Trifluoromethyl)benzo[b]thiophene-2-carbonyl chloride | HCID 57718789 | — |
Reaction Steps
Oxalyl chloride (2.29 mmol, 0.20 mL) was added to a solution of 6-(trifluoromethyl)benzo[b]thiophene-2-carboxylic acid (2.03 mmol, 500 mg) CH2Cl2 (15 mL). DMF (15 μL) was added and the resulting mixture was stirred for 4 h at room temperature. The resulting solution was concentrated to yield 6-(trifluoromethyl)benzo[b]thiophene-2-carbonyl chloride, which was used in the next step without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415341B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-d5695f05b4244d8d8dd051f491608cca |
| Source note | uspto-grants-2013_04 |