Cyanuric chloride → HCID 178478357, compound

Participants

Reaction Steps

To a solution of cyanuric chloride (5 g, 27.1 mmol) in THF (40 mL) were added diisopropylethylamine (7.1 mL, 40.6 mmol) and 3-cyclopropyl-1H-pyrazol-5-amine (4.0 g, 32.5 mmol) in isopropyl alcohol (40 mL) at 0° C. over 30 minutes. The reaction mixture was stirred at room temperature overnight. The crude reaction solution was used for the next step without purification. A small amount was purified by Biotage (0-50% EtOAc/Hexane, 1 L). 1H NMR (DMSO, 400 MHz) δ 11.33 (s, NH), 6.19 (s, 1H), 3.83 (br s, NH), 1.88-1.95 (m, 1H), 0.93-0.96 (m, 2H), 0.68-0.70 (m, 2H). LC/MS [M+H]+: 271/273; Ret time (Method F): 3.00 min.

Provenance & Evidence