(2S,4R)-4-fluoro-N-(6-fluoropyridin-3-yl)pyrrolidine-2-carboxamide → HCID 178522166, compound
Reaction equation
Cl[C:2]1[N:7]=[C:6]([Cl:8])[N:5]=[C:4]([NH:9][C:10]2[NH:14][N:13]=[C:12]([CH:15]3[CH2:17][CH2:16]3)[CH:11]=2)[N:3]=1.[F:18][C@H:19]1[CH2:23][NH:22][C@H:21]([C:24]([NH:26][C:27]2[CH:28]=[N:29][C:30]([F:33])=[CH:31][CH:32]=2)=[O:25])[CH2:20]1.ClC1N=C(NC2NN=C(C3CC3)C=2)N=C(N2CCC[C@@]2(C)C(NC2C=NC(F)=CC=2)=O)N=1>>[Cl:8][C:6]1[N:5]=[C:4]([NH:9][C:10]2[NH:14][N:13]=[C:12]([CH:15]3[CH2:17][CH2:16]3)[CH:11]=2)[N:3]=[C:2]([N:22]2[CH2:23][C@H:19]([F:18])[CH2:20][C@H:21]2[C:24]([NH:26][C:27]2[CH:28]=[N:29][C:30]([F:33])=[CH:31][CH:32]=2)=[O:25])[N:7]=1Participants
4
Procedure
79B was prepared from 1A and 79A as described for 1C: MS: 462/464(M+H)+, HPLC (Method F) Ret time: 2.61 min.
Workup
- custom2.61 min.
Sources & evidence
- ORD record
- ord-e67b081847494550a59ceef2693998d6
- Source dataset
- uspto-grants-2013_04
- Patent number
- US08415340B2
Reaction notes
Loading…