HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Boc-cis-4-hydroxy-L-proline methyl ester → (2S,4S)-4-Hydroxy-N-(pyrazin-2-yl)pyrrolidine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Boc-cis-4-hydroxy-L-proline methyl ester | HCID 10752873 | — |
| Reactant | (2S,4R)-4-Fluoro-N-(pyrazin-2-yl)pyrrolidine-2-carboxamide | HCID 59436310 | — |
| Reactant | (2S,4R)-tert-Butyl 4-fluoro-2-(pyrazin-2-ylcarbamoyl)pyrrolidine-1-carboxylate | HCID 59436441 | — |
| Product | (2S,4S)-4-Hydroxy-N-(pyrazin-2-yl)pyrrolidine-2-carboxamide | HCID 59436319 | — |
Reaction Steps
(2S,4S)-4-Hydroxy-N-(pyrazin-2-yl)pyrrolidine-2-carboxamide 85A was prepared from (2S,4S)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate as described for 65A and 65B. LC/MS [M+H]+: 209; Ret time (Method F): 0.27 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415340B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-2d82c4324c044bd5804463ac10c91e19 |
| Source note | uspto-grants-2013_04 |