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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1961393Generated: October 31, 2026

(2S,4S)-4-Hydroxy-N-(thiazol-2-yl)pyrrolidine-2-carboxamide → (2S,4S)-1-(4-Chloro-6-(5-cyclopropyl-1H-pyrazol-3-ylamino)-1,3,5-triazin-2-yl)-4-hydroxy-N-(thiazol-2-yl)pyrrolidine-2-carboxamide

https://huagongshe.com/reaction/1961393

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2S,4S)-4-Hydroxy-N-(thiazol-2-yl)pyrrolidine-2-carboxamideHCID 28943408—
ReactantHCID 178431741HCID 178431741—
ReactantHCID 178478357HCID 178478357—
Product(2S,4S)-1-(4-Chloro-6-(5-cyclopropyl-1H-pyrazol-3-ylamino)-1,3,5-triazin-2-yl)-4-hydroxy-N-(thiazol-2-yl)pyrrolidine-2-carboxamideHCID 59436431—

Reaction Steps

88B was prepared from 1A and 88A as described for 1C. LC/MS [M+H]+: 448/450; Ret time (Method F): 2.34 min.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08415340B2
Source datasetuspto-grants-2013_04
ORD IDord-675d7904f4e141ad98fb2a4fa3c9930d
Source noteuspto-grants-2013_04