HCID 59436397, compound → HCID 59436402, compound

Participants

Reaction Steps

To nitrogen flushed pressure bottle, were added Pd/C (200 mg) and (2S,4S)-2-benzyl 1-tert-butyl 4-hydroxy-2-methylpyrrolidine-1,2-dicarboxylate (1.4 g, 4.17 mmol) in MeOH (300 mL). The reaction mixture was hydrogenated at 50 psi overnight. The reaction mixture was passed through a pad of celite, washed with MeOH, and concentrated. The residue (0.86 g, 84%) was used for the next step without purification. 1H NMR (CD3OD, 400 MHz) δ 4.32-4.39 (m, 1H), 3.62-3.68 (m, 1H), 3.34-3.37 (m, 1H), 2.12-2.22 (m, 2H), 1.51 and 1.49 (s, 3H), 1.43 and 1.40 (s, 9H).

Provenance & Evidence