Morpholine → HCID 178421462, compound

Participants

Reaction Steps

To a solution of (1S,4S)-5-(4-chloro-6-(3-cyclopropyl-1H-pyrazol-5-ylamino)-1,3,5-triazin-2-yl)-4-methyl-2-oxa-5-azabicyclo[2.2.1]heptan-3-one (365 mg, 1.01 mmol) in THF (10 ml) was added morpholine (0.2 ml, excess). The reaction mixture was stirred at RT for 4 h and concentrated. The residue was purified by prep. HPLC to give 105B (340 mg, 66%) as a TFA salt. LC/MS [M+H]+: 513; Ret time (Method F): 2.56 min.

Provenance & Evidence