(S)-N-(Thiazol-2-yl)pyrrolidine-2-carboxamide → HCID 178522585, compound

HRID 1961407Notes

Reaction equation

HRID 1961407 reaction equation
Cl[C:2]1[N:7]=[C:6]([Cl:8])[N:5]=[C:4]([NH:9][C:10]2[NH:14][N:13]=[C:12]([CH:15]3[CH2:17][CH2:16]3)[CH:11]=2)[N:3]=1.[S:18]1[CH:22]=[CH:21][N:20]=[C:19]1[NH:23][C:24]([C@@H:26]1[CH2:30][CH2:29][CH2:28][NH:27]1)=[O:25].ClC1N=C(NC2NN=C(C3CC3)C=2)N=C(N2CCC[C@@]2(C)C(NC2C=NC(F)=CC=2)=O)N=1>>[Cl:8][C:6]1[N:5]=[C:4]([NH:9][C:10]2[NH:14][N:13]=[C:12]([CH:15]3[CH2:17][CH2:16]3)[CH:11]=2)[N:3]=[C:2]([N:27]2[CH2:28][CH2:29][CH2:30][C@H:26]2[C:24]([NH:23][C:19]2[S:18][CH:22]=[CH:21][N:20]=2)=[O:25])[N:7]=1

Participants

4

Reactant 3

HCID 15870355(S)-N-(Thiazol-2-yl)pyrrolidine-2-carboxamideHCID 178431741HCID 178431741, compoundHCID 178478357HCID 178478357, compound

Product 1

HCID 178522585HCID 178522585, compound

Procedure

(S)-1-(4-Chloro-6-(3-cyclopropyl-1H-pyrazol-5-ylamino)-1,3,5-triazin-2-yl)-N-(thiazol-2-yl)pyrrolidine-2-carboxamide 109B was prepared from 1A and 109A as described for 1C. LC/MS [M+H]+: 432/434; Ret time (Method F): 2.70 min.

Workup

  1. custom2.70 min.

Sources & evidence

ORD record
ord-d7f852d86fc744a0a23dca1b14d00f39
Source dataset
uspto-grants-2013_04
Patent number
US08415340B2

Reaction notes

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