(2S,4S)-4-methoxypyrrolidine-2-carboxylic acid → (2S,4S)-1-(4-(5-Cyclopropyl-1H-pyrazol-3-ylamino)-6-morpholino-1,3,5-triazin-2-yl)-4-methoxypyrrolidine-2-carboxylic acid

HRID 1961409Notes

Reaction equation

HRID 1961409 reaction equation
Cl[C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[N:5]=[C:4]([NH:14][C:15]2[CH:19]=[C:18]([CH:20]3[CH2:22][CH2:21]3)[NH:17][N:16]=2)[N:3]=1.[CH3:23][O:24][C@@H:25]1[CH2:29][NH:28][C@H:27]([C:30]([OH:32])=[O:31])[CH2:26]1>>[CH:20]1([C:18]2[NH:17][N:16]=[C:15]([NH:14][C:4]3[N:5]=[C:6]([N:8]4[CH2:13][CH2:12][O:11][CH2:10][CH2:9]4)[N:7]=[C:2]([N:28]4[CH2:29][C@@H:25]([O:24][CH3:23])[CH2:26][C@H:27]4[C:30]([OH:32])=[O:31])[N:3]=3)[CH:19]=2)[CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 12849452(2S,4S)-4-methoxypyrrolidine-2-carboxylic acidHCID 594364214-Chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)-6-morpholino-1,3,5-triazin-2-amine

Product 1

HCID 59436437(2S,4S)-1-(4-(5-Cyclopropyl-1H-pyrazol-3-ylamino)-6-morpholino-1,3,5-triazin-2-yl)-4-methoxypyrrolidine-2-carboxylic acid

Procedure

Compound 112B was prepared from 112A and (2S,4S)-4-methoxypyrrolidine-2-carboxylic acid as described for 1. LC/MS [M+H]+: 431; Ret time (Method F): 2.27 min.

Workup

  1. custom2.27 min.

Sources & evidence

ORD record
ord-b33a7f289539403a8e54b39277b61fd7
Source dataset
uspto-grants-2013_04
Patent number
US08415340B2

Reaction notes

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