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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1961413Generated: October 30, 2026

Aminopyrazine → (1S,3S,5S)-tert-Butyl 3-(pyrazin-2-ylcarbamoyl)-2-azabicyclo[3.1.0]hexane-2-carboxylate

https://huagongshe.com/reaction/1961413

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAminopyrazineHCID 78747—
Reactant2-tert-butyl 3-methyl (1S,3S,5S)-2-azabicyclo[3.1.0]hexane-2,3-dicarboxylateHCID 58501703—
Reactant(2S,4R)-tert-Butyl 4-fluoro-2-(pyrazin-2-ylcarbamoyl)pyrrolidine-1-carboxylateHCID 59436441—
Product(1S,3S,5S)-tert-Butyl 3-(pyrazin-2-ylcarbamoyl)-2-azabicyclo[3.1.0]hexane-2-carboxylateHCID 59436392—

Reaction Steps

(1S,3S,5S)-tert-Butyl 3-(pyrazin-2-ylcarbamoyl)-2-azabicyclo[3.1.0]hexane-2-carboxylate 121B was prepared from 121A and 2-amino pyrazine using the procedure as reported in 65A. LC/MS [M+H]+: 305; Ret time (Method A): 1.63 min.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08415340B2
Source datasetuspto-grants-2013_04
ORD IDord-7d24efa2c4be4053847d49b8cd5a2fd3
Source noteuspto-grants-2013_04