HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → 4-(Dimethylamino)-3-(trifluoromethyl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | 4-Fluoro-3-(trifluoromethyl)benzonitrile | HCID 144255 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-(Dimethylamino)-3-(trifluoromethyl)benzonitrile | HCID 21732817 | — |
Reaction Steps
4-Fluoro-3-(trifluoromethyl)benzonitrile (240 mg, 1.27 mmol) was dissolved in DMSO (1 ml) together with dimethylamine (1 ml, 40% aq). The mixture was stirred at r.t. for 18 hours followed by 4 hours at 50° C. The reaction was cooled, diluted with EtOAc (10 ml), washed with H2O (2*20 ml), dried over MgSO4 and evaporated to give 253 mg (93%) of the title substance as a greenish oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415333B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-d3516dd8774c4f87ac0800a469488ddb |
| Source note | uspto-grants-2013_04 |