HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1961431Generated: November 1, 2026
4-Fluorobenzonitrile → 4-(Thiomorpholin-4-yl)benzonitrile
https://huagongshe.com/reaction/1961431
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Fluorobenzonitrile | HCID 14517 | — |
| Reactant | Thiomorpholine | HCID 67164 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-(Thiomorpholin-4-yl)benzonitrile | HCID 23292982 | 53.3% |
Reaction Steps
4-fluorobenzonitrile (500 mg, 4.13 mmol) and thiomorpholine (1.18 ml, 12.4 mmol) was dissolved in acetonitrile (2 ml) and stirred at 100° C. for 40 hours. The reaction was cooled, evaporated and purified by flash chromatography using pet.ether/EtOAc (4:1) as eluent to give 450 mg (53%) of the title compound as pale solids.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08415333B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-e5166f7fe0984a36b8c559992959d2f0 |
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| Source note | uspto-grants-2013_04 |
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