HCID 66746146, compound → HCID 68089767, compound

Participants

Reaction Conditions

Reaction Steps

In a screw cap pressure tube were tert-butyl 3-bromo-4-(4,4-dimethylpiperidin-1-yl)benzylcarbamate (105 mg, 0.26 mmol) and CuCN (47.3 mg, 0.53 mmol) suspended in DMF (1.0 ml). N2 was bubbled through the suspension for 5 min. The tube was sealed and the mixture heated to 140° C. overnight. The mixture was allowed to cool and then it was poured over ice-water. FeCl3 (94.3 mg, 0.58 mmol) was added and the product extracted with EtOAc. The combined organic extracts were dried (MgSO4), filtered and concentrated. The crude product was purified by flash chromatography (Pet. Ether/EtOAc 4:1) affording 40 mg (45%) of the title compound.

Provenance & Evidence