HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(3,6-dihydro-2H-pyran-4-yl)benzonitrile → 4-(Tetrahydro-2H-pyran-4-yl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(3,6-dihydro-2H-pyran-4-yl)benzonitrile | HCID 66633023 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(Tetrahydro-2H-pyran-4-yl)benzonitrile | HCID 66632976 | 75% |
Reaction Steps
450 mg (2.43 mmol) 4-(3,6-dihydro-2H-pyran-4-yl)benzonitrile was dissolved in 15 ml EtOH and 50 mg 10% Pd/C was added. The reaction mixture was stirred under H2 (4 bar) over night at room temperature. The mixture was filtered through celite with EtOAc washing. The filtrate was concentrated and the crude product 340 mg (75% yield) was used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415333B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-aa96eb4e222b42e7a2776e7850b6b75c |
| Source note | uspto-grants-2013_04 |