HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (4-(tetrahydro-2H-pyran-4-yl)phenyl)methanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 4-(Tetrahydro-2H-pyran-4-yl)benzonitrile | HCID 66632976 | — |
| Catalyst | Nickel Dichloride | HCID 24385 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | (4-(tetrahydro-2H-pyran-4-yl)phenyl)methanamine | HCID 66632713 | — |
Reaction Steps
340 mg (1.82 mmol) 4-(tetrahydro-2H-pyran-4-yl)benzonitrile was reduced according to the general procedure with NiCl2 and NaBH4. The intermediate Boc-protected amine was treated with 2M HCl in diethyl ether to remove the Boc group. The crude was treated with aqueous NaHCO3 and extracted with CH2Cl2 to afford after drying and evaporation 234 mg (67%) of the title compound as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415333B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-cb02278ac7bc4603b1ee21a0a2d30466 |
| Source note | uspto-grants-2013_04 |