HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → Methyl 2-methoxy-1,8-naphthyridine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | Ethyl 2-chloro-1,8-naphthyridine-3-carboxylate | HCID 15067503 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 2-methoxy-1,8-naphthyridine-3-carboxylate | HCID 66633977 | — |
Reaction Steps
Ethyl 2-chloro-1,8-naphthyridine-3-carboxylate (104.0 mg, 0.44 mmol) was dissolved in anhydrous MeOH under N2. NaOMe (33.2 mg, 0.62 mmol) was added as a solution in MeOH. The mixture was refluxed for 15 h, and then it was allowed to cool. NH4Cl (sat) was added and the product extracted with EtOAc. The combined organic extracts were dried (MgSO4), filtered and concentrated to yield 102.0 mg (quant) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415333B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-24bb70f2a26f45e8a37425930245cdb3 |
| Source note | uspto-grants-2013_04 |