Methylamine → Ethyl 2-(methylamino)-1,8-naphthyridine-3-carboxylate

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Reaction Steps

Ethyl 2-chloro-1,8-naphthyridine-3-carboxylate (100 mg, 0.42 eq.) was dissolved in EtOH. MeNH2 (71.8 μl, 11.84 M aqueous solution) was added to the solution. The mixture was stirred at r.t. for 18 h. The solvents were removed under reduced pressure. The residue was dissolved in EtOAc and washed with water (×2). The organic extract was dried (MgSO4), filtered and concentrated to yield 60.2 mg (62%) of the title compound.

Provenance & Evidence