HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1961448Generated: October 31, 2026
Sodium Hydroxide → 2-(Methylamino)-1,8-naphthyridine-3-carboxylic acid
https://huagongshe.com/reaction/1961448
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 2-(methylamino)-1,8-naphthyridine-3-carboxylate | HCID 66745462 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-(Methylamino)-1,8-naphthyridine-3-carboxylic acid | HCID 66633702 | — |
Reaction Steps
Ethyl 2-(methylamino)-1,8-naphthyridine-3-carboxylate (58 mg, 0.25 mmol) was dissolved in EtOH. NaOH (0.75 ml, 1M aqueous solution) was added to the solution and the mixture stirred at 40° C. for 5.0 h. The organic solvent was removed under vacuo. The remaining aqueous residue was treated with HCl (1M aqueous solution) until slightly acidic and the product extracted with EtOAc. The combined organic phases were dried over MgSO4, filtered and concentrated yielding 50.0 mg (quant) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08415333B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-88513ff0f3f642b6af055c6c60df398f |
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| Source note | uspto-grants-2013_04 |
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