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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1961449Generated: October 30, 2026

3-(Trifluoromethyl)benzylamine → 2-(Methylamino)-N-(3-(trifluoromethyl)benzyl)-1,8-naphthyridine-3-carboxamide

https://huagongshe.com/reaction/1961449

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Trifluoromethyl)benzylamineHCID 75962—
Reactant2-(Methylamino)-1,8-naphthyridine-3-carboxylic acidHCID 66633702—
Product2-(Methylamino)-N-(3-(trifluoromethyl)benzyl)-1,8-naphthyridine-3-carboxamideHCID 4690839169%

Reaction Steps

2-(Methylamino)-1,8-naphthyridine-3-carboxylic acid was coupled to 3-(trifluoromethyl)benzylamine using the general amide coupling procedure. The crude product was purified by flash chromatography, CH2Cl2/MeOH 95:5, yielding 62.4 mg (69%) of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08415333B2
Source datasetuspto-grants-2013_04
ORD IDord-3906efd1f80e4c1587d03ac548efe901
Source noteuspto-grants-2013_04