HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylboronic Acid → HCID 68071556, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenylboronic Acid | HCID 66827 | — |
| Reactant | tert-butyl N-(1-(4-bromophenyl)ethyl)carbamate | HCID 11983730 | — |
| Reactant | HCID 46908968 | HCID 46908968 | — |
| Product | HCID 68071556 | HCID 68071556 | — |
Reaction Steps
The title compound was synthesized from tert-Butyl 1-(4-bromophenyl)ethylcarbamate and phenyl boronic acid, following the general procedure for the coupling of aryl bromides with boronic acids (see above and c.f. scheme 27). Purification was done by flash column chromatography using Pet. ether/EtOAc 5:1→100% EtOAc as eluent. The fractions containing product were further purified by size exclusion chromatography Sephadex LH20, CHCl3/MeOH 1:1 yielding the title compound (68%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415333B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-045ecb1ef0a24fcfa41593af84ce38e7 |
| Source note | uspto-grants-2013_04 |