HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → (6-Tert-butylpyridin-3-yl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 6-tert-Butyl-3-formylpyridine | HCID 11240665 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (6-Tert-butylpyridin-3-yl)methanol | HCID 22978684 | 85% |
Reaction Steps
6-tert-Butylnicotinaldehyde (363.0 mg, 2.22 mmol) was dissolved in EtOH (20 ml). NaBH4 (193.5 mg, 5.12 mmol) was added. The mixture was stirred at r.t. for 1.0 h. The solvent was removed under reduced pressure. The residue was suspended in aqueous Na2CO3 and the product extracted with EtOAc. The combined organic extracts were dried (MgSO4), filtered and concentrated yielding 311.5 mg the title compound as a colourless oil (85%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415333B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-257130de09d74c91acb505135728ec3c |
| Source note | uspto-grants-2013_04 |