Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | HCID 66633913 | HCID 66633913 | — |
| Product | HCID 66634229 | HCID 66634229 | 63.3% |
Reaction Steps
In a screw cap pressure tube ethyl 4-chloro-2-methyl-1,8-naphthyridine-3-carboxylate (250 mg, 1.0 mmol) was suspended in piperidine (2.0 ml, 20 mmol). The tube was sealed and the mixture heated to 80° C. for 1.0 h. The mixture was then adsorbed on silica and chromatographed (CH2Cl2/MeOH 98:2→97:3) giving 189.4 mg (63%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08415333B2 |
|---|
| Source dataset | uspto-grants-2013_04 |
|---|
| ORD ID | ord-52dacb5d0a614a6d9126c4c4f85335b2 |
|---|
| Source note | uspto-grants-2013_04 |
|---|
