反应详情

温度

0 °C

4-Amino-3-nitro-benzimidic acid ethyl ester hydrochloride (84.5 g, 344 mmol) was suspended in absolute ethanol (750 mL) and then cooled to 0° C. Ammonia was then passed through the solution for a period of 2 h. The flask was tightly sealed and allowed to warm up to room temperature over an 18 h period with stirring. The product was crystallized with diethyl ether and the resulting solid was filtered, washed and dried to give 4-amino-3-nitrobenzamidine monohydrochloride (70.7 g) as an off-white powder.

1. customThe flask was tightly sealed
2. temperatureto warm up to room temperature over an 18 h period
3. customThe product was crystallized with diethyl ether
4. filtrationthe resulting solid was filtered
5. washwashed
6. customdried