反应详情

3-amino-1-phenyl-1H-pyrazole-4-carbonitrile (0.34 g, 1.846 mmol) was stirred in 95% H2SO4 (10 mL) at 50° C. for 3 hours. Room temperature was attained, water was added and the products extracted into EtOAc (×3). The aqueous phase was neutralised with 2 N NaOH and the products extracted into DCM (×2) followed by 20% MeOH-DCM (×4). The combined organic extracts were dried over MgSO4 and concentrated in vacuo. The residue was triturated in EtOAc to give 3-amino-1-phenyl-1H-pyrazole-4-carboxamide as a pale yellow solid.

1. customRoom temperature
2. extractionthe products extracted into EtOAc (×3)
3. extractionthe products extracted into DCM (×2)
4. dry with materialThe combined organic extracts were dried over MgSO4
5. concentrationconcentrated in vacuo
6. customThe residue was triturated in EtOAc