HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Diisopropylethylamine → 4-(4-Iodobenzyl)thiomorpholine 1,1-dioxide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Diisopropylethylamine | HCID 81531 | — |
| Edukt | 4-Iodobenzyl bromide | HCID 954258 | — |
| Edukt | Thiomorpholine 1,1-dioxide | HCID 6484228 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | 4-(4-Iodobenzyl)thiomorpholine 1,1-dioxide | HCID 58285156 | — |
Reaktionsschritte
1-(bromomethyl)-4-iodobenzene (1 g, 3.37 mmol), thiomorpholine 1,1-dioxide (0.546 g, 4.04 mmol) and DIPEA (0.882 mL, 5.05 mmol) were stirred in THF (15 mL) at room temperature overnight. The solvent was removed in vacuo while loading onto silica. Purification of the residue by MPLC (12-100% EtOAc-hexanes) gave 4-(4-iodobenzyl)thiomorpholine 1,1-dioxide as a white solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08415346B2 |
| Quelldatensatz | uspto-grants-2013_04 |
| ORD ID | ord-905b96efb93c486e827d7e09bc522802 |
| Quellennotiz | uspto-grants-2013_04 |