Hydrochloric Acid → HCID 178504790, compound

Participants

Reaction Steps

5-{[4-(methylsulfonyl)phenyl]amino}-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrazole-4-carbonitrile (0.82 g, 2.089 mmol) was stirred in ethanol (40 mL)/2 N HCl (40 mL) at 80° C. for 2 hours. Room temperature was attained, saturated NaHCO3 was added and the products extracted into EtOAc (×2). The combined organic extracts were washed with brine, dried over MgSO4 and concentrated in vacuo to give 3-{[4-(methylsulfonyl)phenyl]amino}-1H-pyrazole-4-carbonitrile as a pale yellow solid.

Provenance & Evidence