4-Acetylphenylboronic acid → HCID 67253197, compound

HRID 1961519Notes

Reaction equation

HRID 1961519 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]2[C:16]([C:17]#[N:18])=[CH:15][NH:14][N:13]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3].[C:19]([C:22]1[CH:27]=[CH:26][C:25](B(O)O)=[CH:24][CH:23]=1)(=[O:21])[CH3:20]>>[C:19]([C:22]1[CH:27]=[CH:26][C:25]([N:14]2[CH:15]=[C:16]([C:17]#[N:18])[C:12]([NH:11][C:8]3[CH:7]=[CH:6][C:5]([S:2]([CH3:1])(=[O:3])=[O:4])=[CH:10][CH:9]=3)=[N:13]2)=[CH:24][CH:23]=1)(=[O:21])[CH3:20]

Participants

3

Reactant 2

HCID 37021224-Acetylphenylboronic acidHCID 178504790HCID 178504790, compound

Product 1

HCID 67253197HCID 67253197, compound

Procedure

1-(4-acetylphenyl)-3-{[4-(methylsulfonyl)phenyl]amino}-1H-pyrazole-4-carbonitrile was prepared according to the general procedure in Example 15 Step 4 using 3-{[4-(methylsulfonyl)phenyl]amino}-1H-pyrazole-4-carbonitrile (0.24 g, 0.915 mmol) and (4-acetylphenyl)boronic acid (0.300 g, 1.830 mmol) as the starting materials.

Sources & evidence

ORD record
ord-de4c2c23bedb4ca6be9b405df401507f
Source dataset
uspto-grants-2013_04
Patent number
US08415346B2

Reaction notes

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