Hydrochloric Acid → HCID 58079827, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl 3-(4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)-3-fluoroazetidine-1-carboxylate (Preparation 14) in methanol (10 mL) was added a methanolic solution of HCl (10 mL of 1.25 M). Reaction mixture warmed to 65° C. for 1.5 hours. Reaction concentrated via rotavap to yield a viscuous oil. CH2Cl2 was added and a precipitate formed. Volatiles removed under reduced pressure to yield 573 mg of the title compound as a white solid. 1H NMR (DMSO-d6) δ 9.8-9.6 (br s, 2H) 7.9-7.8 (m, 3H), 7.75 (d, 2H), 7.63 (d, 2H), 4.64-4.29 (m, 6H)). LC/MS retention time=3.039 minutes, MS calculated for (C19H14Cl2F4N2O), 432.04; found 433.0 M+H.

Provenance & Evidence