HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorophenylglyoxylic acid → 3-(4-chlorophenyl)-1-(2,2-difluoroethyl) quinoxalin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorophenylglyoxylic acid | HCID 145998 | — |
| Reactant | N-(2,2-difiuoroethyl)benzene-1,2-diamine | HCID 58110951 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(4-chlorophenyl)-1-(2,2-difluoroethyl) quinoxalin-2(1H)-one | HCID 44224485 | 32% |
Reaction Steps
To a solution of 400 mg (2,32 mM) of N-(2,2-difluoroethyl)benzene-1,2-diamine in 7 ml of methanol were added 428 mg (2,32 mM) of 4-chloro-α-oxo-benzeneacetic acid. The mixture was refluxed for 3 h. A solid was filtered, washed and dried under vacuum to give 236 mg of 3-(4-chlorophenyl)-1-(2,2-difluoroethyl) quinoxalin-2(1H)-one Yield: 32%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415352B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-ec45fbcb22614a7389a316755d72064c |
| Source note | uspto-grants-2013_04 |