Ethyl Acetate → HCID 86648339, compound

Participants

Reaction Steps

5-[2-((S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-5-methyl-hexahydro-cyclopenta[c]pyrrole-2-carboxylic acid dimethylamide 11d (20 mg, 0.057 mmol) and p-toluenesulfonic acid monohydrate (12 mg, 0.063 mmol) were dissolved in 2 mL of dichloromethane with stirring upon cooling by an ice-water bath. The reaction mixture was stirred for 10 minutes at the same temperature and the ice-water bath was removed. The mixture was concentrated under reduced pressure to obtain an oil. The mixture was treated with 5 mL of ethyl acetate with stirring to produce a white precipitate. The mixture was filtered under reduced pressure to obtain the title compound 5-[2-((S)-2-cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-5-methyl-hexahydro-cyclopenta[c]pyrrole-2-carboxylic acid dimethylamide p-toluenesulfonate 11 (0.026 g, yield 86.8%) as a white solid.

Provenance & Evidence