2,3-Dihydroxybutanedioic Acid → HCID 68777215, compound

Participants

Reaction Steps

5-Benzyl-5-[2-((S)-2-cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-hexahydro-cyclopenta[c]pyrrole-2-carboxylic acid dimethylamide 17a (56 mg, 0.132 mmol) was dissolved in 1 mL of ethyl acetate with stirring followed by addition of a solution of 1 mL of tartaric acid in acetone. The reaction mixture was stirred for 30 minutes resulting in the formation of a white precipitate followed by addition of n-hexane, and stirred again. The mixture was filtered to obtain the title compound 5-benzyl-5-[2-((S)-2-cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-hexahydro-cyclopenta[c]pyrrole-2-carboxylic acid dimethylamide tartrate 17 (50 mg, yield 67%) as a white solid.

Provenance & Evidence