2,3-Dihydroxybutanedioic Acid → HCID 68775604, compound

Participants

Reaction Steps

5-[2-((S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-5-ethyl-hexahydro-cyclopenta[c]pyrrole-2-carboxylic acid dimethylamide 19g (120 mg, 0.33 mmol) was dissolved in 1 mL of ethyl acetate followed by dropwise addition of a solution of 2 mL of tartaric acid (50 mg, 0.33 mmol) in acetone. The reaction mixture was stirred for 30 minutes and filtered to obtain the title compound 5-[2-((S)-2-cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-5-ethyl-hexahydro-cyclopenta[c]pyrrole-2-carboxylic acid dimethylamide tartrate 19 (160 mg, yield 94%) as a white solid.

Provenance & Evidence