HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → Quinoxaline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Quinoxaline | HCID 7045 | — |
Reaction Steps
Compounds of structure H may be prepared as illustrated in Scheme 2. Reaction of a carboxylic acid E with various hydrazides in the presence of EDCI and HOBt in DMSO yields quinoxaline F. Quinoxaline F may then be treated with phosphorus oxychloride to give quinoxaline G. Subsequent reaction of quinoxaline G with ammonia at elevated temperature then provides compounds H.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415353B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-1bd9d3816bab4169906fe9477a90f182 |
| Source note | uspto-grants-2013_04 |