Trifluoroacetic acid → HCID 66627784, Verbindung

HRID 1961634Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1961634
C(OC([N:8]1[CH2:13][CH2:12][C:11]([F:23])([C:14](=[O:22])[C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O.C([O-])(O)=O.[Na+]>ClCCl>[F:23][C:11]1([C:14](=[O:22])[C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Komponenten

5

Edukt 3

HCID 6422Trifluoroacetic acidHCID 516892Sodium BicarbonateHCID 179792081,1-Dimethylethyl 4-fluoro-4-(4-fluorobenzoyl)-1-piperidinecarboxylate

Produkt 1

HCID 66627784HCID 66627784, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

4-Fluoro-4-(4-fluoro-benzoyl)-piperidine-1-carboxylic acid tert-butyl ester (0.122 g, 0.375 mmol) was solved in dichloromethane (2 mL) and trifluoroacetic acid (0.258 mL, 3.37 mmol) was added at 0° C. Aqueous NaHCO3 is slowly added until pH 9 and the mixture extracted with 3 times with dichloromethane and ethyl acetate. The solvent was evaporated to yield g (0. mmol, 100%) of a white solid that was used without purification on the next steps. MS (m/e): 226.1 (M+H+).

Aufarbeitung

  1. extractionthe mixture extracted with 3 times with dichloromethane and ethyl acetate
  2. customThe solvent was evaporated
  3. customto yield g (0. mmol, 100%) of a white solid that
  4. customwas used without purification on the next steps

Quellen und Nachweise

ORD-Eintrag
ord-ac7015ced7b24e7cb3c0505fc8af4051
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08415350B2

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