HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1961645Generated: October 30, 2026
1,4-Dichlorobenzene → 4-(2,4-dichlorobenzoyl)-N-acetylpiperidine
https://huagongshe.com/reaction/1961645
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,4-Dichlorobenzene | HCID 4685 | — |
| Reactant | 1-Acetylpiperidine-4-carbonyl chloride | HCID 100950 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Product | 4-(2,4-dichlorobenzoyl)-N-acetylpiperidine | HCID 13076387 | 50% |
Reaction Steps
Acetylisonipecotoyl chloride (8 g, 42 mmol) was solved in dichlorobenzene and aluminium chloride (11.2 gr, 894 mmol) was added portionwise. The mixture was refluxed at 90° C. for 4 h after complexion of the reaction. Ice/water was added to the mixture that was extracted with dichloromethane. After chromatography from heptane to EtOAc the product was obtained as a yellow oil (6.3 g, 50%). MS (m/e): 300.2 (M+H+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08415350B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-a43d933d800b4d0e8abf6cc10bc97ee3 |
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| Source note | uspto-grants-2013_04 |
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