1-Acetylpiperidine-4-carbonyl chloride → HCID 66628070, compound

HRID 1961648Notes

Reaction equation

HRID 1961648 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1I.C([Mg]Cl)(C)C.[Cl-].[Li+].[C:17]([N:20]1[CH2:28][CH2:27][CH:23]([C:24](Cl)=[O:25])[CH2:22][CH2:21]1)(=[O:19])[CH3:18]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:24]([CH:23]1[CH2:22][CH2:21][N:20]([C:17](=[O:19])[CH3:18])[CH2:28][CH2:27]1)=[O:25]

Participants

4

Reactant 3

HCID 1009501-Acetylpiperidine-4-carbonyl chlorideHCID 1224521,4-Dichloro-2-iodobenzeneHCID 178461733HCID 178461733, compound

Product 1

HCID 66628070HCID 66628070, compound

Procedure

The title compound was prepared according as described on example 65A18 from 2,5 Dichloro 1-iodobenzol, isopropyl magnesium chloride-lithium chloride (2M in THF) and 1-acetyl-isonipecotoyl chloride. (m/e): 301.1 (M+H+).

Sources & evidence

ORD record
ord-220b4b13a20a4675886e96d8035a7088
Source dataset
uspto-grants-2013_04
Patent number
US08415350B2

Reaction notes

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