Acetic Acid → HCID 178474965, compound

HRID 1961652Notes

Reaction equation

Cl.Cl.[NH2:3][C@H:4]1[CH2:9][CH2:8][C@H:7]([CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][CH:15]([C:18]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:19])[CH2:14][CH2:13]2)[CH2:6][CH2:5]1.[C:26](O)(=[O:28])[CH3:27]>>[C:18]([CH:15]1[CH2:16][CH2:17][N:12]([CH2:11][CH2:10][C@H:7]2[CH2:8][CH2:9][C@H:4]([NH:3][C:26](=[O:28])[CH3:27])[CH2:5][CH2:6]2)[CH2:13][CH2:14]1)(=[O:19])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

Reactant 2

HCID 176Acetic Acid

HCID 178478714HCID 178478714, compound

Product 1

HCID 178474965HCID 178474965, compound

Procedure

From {1-[2-(trans-4-amino-cyclohexyl)-ethyl]-piperidin-4-yl}-phenyl-methanone dihydrochloride (138 mg) and acetic acid (23 mg) by procedure C. Yield: 85 mg (66%). White solid. 357.3 ([M+H]+).

Sources & evidence

ORD record: ord-ebab6d10a4f64d2da51e1a5f96ea0290
Source dataset: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08415350B2

Reaction notes

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