4-(4-Chlorobenzoyl)piperidine hydrochloride → HCID 178453899, compound

HRID 1961653Notes

Reaction equation

HRID 1961653 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)=[O:10])=[CH:5][CH:4]=1.[C:17]([O:21][C:22](=[O:33])[NH:23][C@H:24]1[CH2:29][CH2:28][C@H:27]([CH2:30][CH:31]=O)[CH2:26][CH2:25]1)([CH3:20])([CH3:19])[CH3:18]>>[C:17]([O:21][C:22](=[O:33])[NH:23][C@H:24]1[CH2:25][CH2:26][C@H:27]([CH2:30][CH2:31][N:14]2[CH2:15][CH2:16][CH:11]([C:9](=[O:10])[C:6]3[CH:7]=[CH:8][C:3]([Cl:2])=[CH:4][CH:5]=3)[CH2:12][CH2:13]2)[CH2:28][CH2:29]1)([CH3:20])([CH3:19])[CH3:18]

Participants

3

Reactant 2

HCID 27771144-(4-Chlorobenzoyl)piperidine hydrochlorideHCID 178453924HCID 178453924, compound2×

Product 1

HCID 178453899HCID 178453899, compound

Procedure

From (4-chlorophenyl)(4-piperidyl)methanone hydrochloride (100 mg) and [trans-4-(2-oxo-ethyl)-cyclohexyl]-carbamic acid tert-butyl ester (intermediate C, 102 mg) by procedure A.1. Yield: 128 mg (74%). Light yellow solid. MS (m/z): 449.3 ([M+H]+).

Sources & evidence

ORD record
ord-fdc980045f5544fb828bdceff2e27bc0
Source dataset
uspto-grants-2013_04
Patent number
US08415350B2

Reaction notes

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