4-(Morpholin-4-yl)benzoic acid → HCID 178523662, compound

HRID 1961654Notes

Reaction equation

HRID 1961654 reaction equation
Cl.Cl.[NH2:3][C@H:4]1[CH2:9][CH2:8][C@H:7]([CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][CH:15]([C:18]([C:20]3[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=3)=[O:19])[CH2:14][CH2:13]2)[CH2:6][CH2:5]1.[N:27]1([C:33]2[CH:41]=[CH:40][C:36]([C:37](O)=[O:38])=[CH:35][CH:34]=2)[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1>>[Cl:26][C:23]1[CH:24]=[CH:25][C:20]([C:18]([CH:15]2[CH2:14][CH2:13][N:12]([CH2:11][CH2:10][C@H:7]3[CH2:8][CH2:9][C@H:4]([NH:3][C:37](=[O:38])[C:36]4[CH:35]=[CH:34][C:33]([N:27]5[CH2:32][CH2:31][O:30][CH2:29][CH2:28]5)=[CH:41][CH:40]=4)[CH2:5][CH2:6]3)[CH2:17][CH2:16]2)=[O:19])=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 3452784-(Morpholin-4-yl)benzoic acidHCID 178478715HCID 178478715, compound

Product 1

HCID 178523662HCID 178523662, compound

Procedure

From {1-[2-(trans-4-amino-cyclohexyl)-ethyl]-piperidin-4-yl}-(4-chloro-phenyl)-methanone dihydrochloride (100 mg) and 4-morpholin-4-yl-benzoic acid. Yield: 56 mg (40%). MS (m/z): 538.5 ([M+H]+).

Sources & evidence

ORD record
ord-238a2c564cd8438dbe2facf57c9a78ac
Source dataset
uspto-grants-2013_04
Patent number
US08415350B2

Reaction notes

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