3-Chlorothiophene → HCID 66627619, compound

HRID 1961660Notes

Reaction equation

HRID 1961660 reaction equation
[Cl:1][C:2]1[CH:6]=[CH:5][S:4][CH:3]=1.[C:7]([O:11][C:12]([N:14]1[CH2:19][CH2:18][CH:17]([CH:20]=[O:21])[CH2:16][CH2:15]1)=[O:13])([CH3:10])([CH3:9])[CH3:8]>>[C:7]([O:11][C:12]([N:14]1[CH2:19][CH2:18][CH:17]([CH:20]([C:3]2[S:4][CH:5]=[CH:6][C:2]=2[Cl:1])[OH:21])[CH2:16][CH2:15]1)=[O:13])([CH3:10])([CH3:9])[CH3:8]

Participants

3

Reactant 2

HCID 870173-ChlorothiopheneHCID 1514430tert-Butyl 4-formylpiperidine-1-carboxylate

Product 1

HCID 66627619HCID 66627619, compound

Procedure

From 3-chlorothiophene (612 mg) and 4-formyl-piperidine-1-carboxylic acid tert-butyl ester (1.00 g) by procedure D. Yield: 420 mg (27%). Yellow solid. MS (m/z): 332.2 ([M+H]+).

Sources & evidence

ORD record
ord-f8881ff7d2934a63bd168a41ba1761bc
Source dataset
uspto-grants-2013_04
Patent number
US08415350B2

Reaction notes

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